A musician and record producer, Enrico has been working in music since 1983, beginning his recording career with the band FARD and several hit singles for EMI and CGD.
He was an intense session man and turn player in the 1980s, participating in hundreds of recordings in various musical genres.

His experience with world-class producers also enabled him to become a record producer, working with labels such as GALA in Italy and LabelBleu and Verve in France.
In the Italian jazz sector, he has produced and released numerous albums with artists such as Enrico Rava, Roberto Gatto, Maurizio Giammarco, Franco D'Andrea, Umberto Fiorentino, Francesco Bruno, Nico Stufano, Enrico Pierannunzi, and Romano Mussolini.
He won Musica Jazz magazine's award for best Italian producer four consecutive times from 1988 to 1992.
He has also produced foreign artists such as Dizzy Gillespie, Dee Dee Bridgewater, Paul Bley, Lee Konitz, Richard Galliano, Richie Havens, London Community Gospel Choir, Crystal White and others.

He has participated in various collaborations in pop and dance music, and in 1999 reached the top of the sales charts in Scandinavia with Arvingarna.

He was part of the legendary 1960s group I Giganti with whom he has 4 tours and an appearance at the Sanremo Festival to his credit, plus various TV appearances.
In 2014 he joined the international project "Hit Italy," and in 2018 he co-produced with Siggi Bemm the album "Funkodrome" under the new name Mr.E.

Santacatterina has collaborated with the largest musical instrument companies and has given clinics and master classes all over the world.
He is currently involved with various musical projects, as a soloist, in Riccardo Fogli 's band and others, such as the duo formed with singer Chiara Pastò.